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Symptoms of Withdrawal

Prescription Drug Opioid and Heroin

  • Muscle and bone pain
  • Cold flashes with goose bumps (“cold turkey”)
  • Vomiting
  • Inability to sleep
  • Diarrhea
  • Involuntary leg movements
  • Strong craving for the drug


Major withdrawal symptoms peak between 24–48 hours after the last dose of heroin and subside after about a week. However, some people have shown persistent withdrawal signs for many months.

Source: U.S. Department of Health and Human Services, Heroin Research Report Series. View here.